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N-reductions occur in azo- or nitro-compounds (e. g. , nitrazepam). Nitro groups can be reduced to amine groups via nitroso and hydroxylamino intermediates. Likewise, dehalogenation is a reductive process involving a carbon atom (e. g. , halothane, p. 218).
Inactivation in plasma is very rapid; during one passage through the lung, 90% of PG circulating in plasma are degraded. PG are local mediators that attain biologically effective concentrations only at their site of formation. Biological effects. The individual PG (PGE, PGF, PGI = prostacyclin) possess different biological effects. Nociceptors. |
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