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Morphine can be given orally or parenterally, as well as epidurally or intrathecally in the spinal cord. The opioids heroin and fentanyl are highly lipophilic, allowing rapid entry into the CNS.
Prior to its uptake into the blood (i.e., during absorption), a drug has to overcome barriers that demarcate the body from its surroundings, i.e., separate the internal milieu from the external milieu. These boundaries are formed by the skin and mucous membranes.

 

The cough-suppressant (antitussive) effect produced by inhibition of the cough reflex is independent of the effects on nociception or respiration (antitussives: codeine. noscapine). Stimulation of chemoreceptors in the area postrema (p. 330) results in vomiting, particularly after first-time administration or in the ambulant patient
In terms of their positive inotropic effect, ?-sympathomimetics, unlike dopamine, are of little therapeutic use; they are also arrhythmogenic and the sensitivity of the ?-receptor system declines during continuous stimulation. Treatment Principles in Chronic Heart Failure Myocardial insufficiency leads to a decrease in stroke volume and venous congestion with formation of edema.

 

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