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Anticoagulant efficacy varies with chain length. The potency of a preparation is standardized in international units of activity (IU) by bioassay and comparison with a reference preparation.
They appear to prevent specifically the resealing of opened strands and thereby act bactericidally. These agents are absorbed after oral ingestion. The older drug, nalidixic acid, affects exclusively gram-negative bacteria and attains effective concentrations only in urine; it is used as a urinary tract antiseptic. Norfloxacin has a broader spectrum.

 

On the basis of these parameters, differences between drugs can be quantified. As a rule, the therapeutic effect or toxic action depends critically on the response of a single organ or a limited number of organs, e. g. , blood flow is affected by a change in vascular luminal width.
At relatively high dosage (> 4 g/d), ASA (p. 198) may exert antiinflammatory effects in rheumatic diseases (e. g. , rheumatoid arthritis). In this dose range, central nervous signs of overdosage may occur, such as tinnitus, vertigo, drowsiness, etc. The search for better tolerated drugs led to the family of nonsteroidal antiinflammatory drugs (NSAIDs).

 

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